Food Allergies, Sensitivities & Intolerances: How to Tell the Difference & Find Relief
April 3, 2025
Rhya Pachin

The Science Behind Food Reactions


While food allergies, sensitivities, and intolerances can cause similar symptoms, their underlying mechanisms are distinct. Allergies involve an immediate immune response, sensitivities trigger delayed inflammation, and intolerances stem from digestive challenges. Identifying which reaction you’re experiencing is key to managing symptoms and making informed dietary choices!





FOOD ALLERGIES:  A Rapid Immune Response


Food allergies occur when the immune system mistakenly identifies a food protein as a harmful invader and releases IgE antibodies to attack it. This triggers an immediate reaction, which can range from mild symptoms like hives and swelling to severe anaphylaxis. Even the smallest amount of an allergen can cause a reaction, making cross-contamination a significant concern.


  • Governed by IgE antibodies, which recognize allergens and trigger histamine release.
  • Symptoms appear within minutes to hours and can be life-threatening.
  • Common allergens: Peanuts, shellfish, dairy, tree nuts, eggs, and soy.


Research Spotlight: Food allergies affect about 6-8% of children and 3% of adults worldwide, with prevalence on the rise.✨



FOOD SENSITIVITES:  A Delayed Inflammatory Response


Unlike allergies, food sensitivities involve a more subtle immune system response. The body may produce inflammatory molecules such as cytokines, leukotrienes, and prostaglandins, leading to low-grade, systemic inflammation. These reactions are often dose-dependent, meaning   symptoms may only appear after repeated exposure over time. Many people experience symptoms such as digestive discomfort, migraines, joint pain, and skin issues without realizing that their diet may be playing a role.


  • Symptoms take 24-96 hours to appear, making it hard to pinpoint the cause.
  • Common culprits: Gluten, dairy, eggs, soy, artificial additives.
  • Often dose-dependent, meaning repeated exposure can increase symptoms.


Science Spotlight: Emerging studies link food sensitivities to conditions like IBS, migraines, joint pain, and brain fog due to their inflammatory nature.✨


Many people assume they have a food allergy when, in reality, they may be dealing with a sensitivity or an intolerance.


These reactions may share some overlapping symptoms, but they differ in their causes, severity, and how they affect the body. Understanding these distinctions can help pinpoint the root cause of your symptoms and guide you toward the right solutions!


FOOD INTOLLERANCES:  A Mechanical Breakdown Issue


Food intolerances differ from allergies and sensitivities because they are not immune-related. Instead, they occur due to enzyme deficiencies or disruptions in gut flora, making it difficult for the body to properly digest certain foods. A classic example is lactose intolerance, where a lack of lactase enzyme prevents the body from breaking down lactose, leading to bloating and diarrhea. Other examples include fructose malabsorption and histamine intolerance, where the body struggles to process naturally occurring food chemicals.


  • Caused by enzyme deficiencies or gut microbiome imbalances.
  • Symptoms often include gas, bloating, diarrhea, and stomach pain.
  • Common examples:
  • Lactose intolerance: Deficiency in lactase enzyme.
  • Fructose malabsorption: Poor absorption of fructose in the intestines.
  • Histamine intolerance: Difficulty breaking down histamine-rich foods (e.g., aged cheese, wine).


Research Spotlight: Approximately 68% of the world's population has lactose malabsorption, which can lead to lactose intolerance symptoms.✨




How to Identify Your Food Reactions


If you're experiencing unexplained symptoms, determining whether it’s an allergy, sensitivity, or intolerance can be challenging. Here’s where to start:


Step 1: Track Your Symptoms

  • Keep a detailed food journal tracking what you eat and how you feel afterward.
  • Look for patterns: Do symptoms appear immediately or hours/days later?



Step 2: Try an Elimination Diet

  • Remove suspected trigger foods for 2-4 weeks.
  • Slowly reintroduce them one at a time to observe reactions.
  • This is especially useful for food sensitivities and intolerances.



Step 3: Consider Lab Testing

  • Food Allergy Testing: IgE blood test or skin prick test.
  • Food Sensitivity Testing: MRT (Mediator Release Test) or IgG-based tests.
  • Food Intolerance Testing: Lactose, fructose, or histamine intolerance tests.
  • Expert Tip: MRT is one of the most comprehensive sensitivity tests, measuring both chemical and food-related inflammatory responses.



Step 4: Work with a Functional Nutritionist

  • If you’re struggling to identify the root cause of your symptoms, a professional can help tailor a nutrition plan and recommend the best approach.




Take the Next Step Toward Relief


If you're unsure whether your symptoms are due to an allergy, sensitivity, or intolerance, you're not alone! Getting to the root cause can help you make informed dietary choices and improve your quality of life.


🔎 Take our Symptom Analysis Quiz
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Ready to get answers? Book your Jumpstart Call today!


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About the Author

Rhya Pachin is a licensed dietitian nutritionist who employs an "integrative" approach to support overall health rather than addressing just one symptom. As a certified LEAP therapist, she designs and supervises custom elimination diets. Her focus areas include gastrointestinal conditions like IBS and IBD, autoimmune diseases such as rheumatoid arthritis and Hashimoto's, persistent weight issues, food sensitivities, and chronic inflammatory conditions in both adults and children.

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